What we do
The Banovich Lab is focused on understanding how gene regulatory changes alter disease risk, progression, and treatment response. The lab employs a combination of experimental and computational approaches, integrating molecular biology, genomics, and computational biology. We specialize in generating and analyzing multi-omic datasets, with a particular focus on identifying genetic variation associated with changes in gene regulatory phenotypes. Aided by novel single cell and spatial genomic technologies, our research continues to move towards profiling gene regulation at cell-type resolution. Our lab also heavily relies on a team science approach, coupling our expertise in functional genomics with researchers and clinicians with domain expertise in specific disease areas and human populations. By studying gene regulatory changes in relevant tissue samples, at cell-type resolution, and in the proper disease and treatment context, we are well positioned to make a translational impact.
We have ongoing research in the following areas:
Chronic lung disease
CAR T cell therapy for the treatment of brain tumors
Genomic architecture of gene regulation in Indonesia
Identifying QTLs at cell-type resolution
Analysis of image based spatial transcriptomics
See more details on our Projects page.